Accelerating GPRC5D Therapy: Proteins, mAbs and CAR-T

GPRC5D plays a pivotal role in cancer and immunology research, garnering significant industry attention. At DIMA Biotechnology, we provide essential tools for exploring this promising target. Our offerings include functional active proteins and specialized antibodies, with a particular focus on GPRC5D CAR-T molecules, which have progressed from leads to Investigator-Initiated Trial (IIT) clinical trial stages in collaboration with our partners. Preliminary data from ongoing clinical trials showcase remarkable clinical efficacy, particularly in treating RRMM patients. Our proprietary technology platforms streamline drug discovery processes, offering comprehensive support to expedite therapeutic research and development.

GPRC5D Flyer

GPRC5D Background

In recent developments, LaNova’s LM-305, an ADC targeting GPRC5D, secured an exclusive global license with AstraZeneca, resulting in an immediate payment of $55 million and the potential for milestone payments totaling $545 million. Concurrently, OriCell Therapeutics introduced OriCAR-017, marking China’s first CAR-T cell therapy designed to target GPRC5D. Additionally, Janssen’s talquetamab, a GPRC5D/CD3 bispecific antibody, displayed promising results in treating RRMM patients, with an anticipated U.S. launch as early as 2024. These advancements underscore the dynamic landscape of GPRC5D-targeted drugs and their potential to revolutionize the pharmaceutical industry.

GPRC5D Products

SKU:  DME100061B     Target:  GPRC5D

Price: 10μg $139.00 ; 100 μg $657.00 ; 500 μg $1971.00

Full Length Transmembrane Proteins

Human GPRC5D full length protein-MNP

SKU:  FLP200011     Target:  GPRC5D

Price: 50 μg $1200.00 ; 100 μg $1600.00

Biosimilar reference antibodies

Anti-GPRC5D(LBL-034 biosimilar) mAb

SKU:  BME100193     Target:  GPRC5D

Price: 50μg $82.00 ; 100 μg $162.00

Biosimilar reference antibodies

Anti-GPRC5D(LM305 biosimilar) mAb

SKU:  BME100187     Target:  GPRC5D

Price: 50μg $82.00 ; 100 μg $162.00

Full Length Transmembrane Proteins

Human GPRC5D full length protein-synthetic nanodisc

SKU:  FLP100011     Target:  GPRC5D

Price: 10 μg $900.00 ; 50 μg $4400.00 ; 100 μg $8000.00

Full Length Transmembrane Proteins

Human GPRC5D full length protein-exo

SKU:  FLP100010     Target:  GPRC5D

Price: 50 μg $1200.00 ; 100 μg $1600.00

SKU:  PME100559P     Target:  GPRC5D

Price: 25test $340.00

SKU:  DME100091P     Target:  GPRC5D

100 test $550.00

SKU:  DME100091B     Target:  GPRC5D

Price: 10μg $139.00 ; 100 μg $670.00 ; 500 μg $1999.00

DimAb monoclonal antibodies

Anti-GPRC5D antibody(DM91); Rabbit mAb

SKU:  DME100091     Target:  GPRC5D

Price: 10μg $99.00 ; 100 μg $446.00 ; 500 μg $1340.00

DimAb monoclonal antibodies

Anti-GPRC5D antibody(DM61); Rabbit mAb

SKU:  DME100061     Target:  GPRC5D

Price: 10μg $99.00 ; 100 μg $446.00 ; 500 μg $1340.00

Biosimilar reference antibodies

Anti-GPRC5D (Talquetamab biosimilar) mAb

SKU:  BME100072     Target:  GPRC5D

Price: 50μg $82.00 ; 100 μg $162.00

SKU:  PME100561     Target:  GPRC5D

Price: 10μg $68.00; 50μg $259.00 ; 100 μg $389.00

SKU:  PME100560     Target:  GPRC5D

Price: 10μg $68.00; 50μg $259.00 ; 100 μg $389.00