| Tag | C-Flag Tag |
|---|---|
| Target | |
| Synonyms | GPCR, MGRG2, MRGX1, SNSR4 |
| Description | Human MRGX1 full length protein-synthetic nanodisc |
| Delivery | 6~8weeks |
| Uniprot ID | Q96LB2 |
| Expression Host | HEK293 |
| Protein Families | GPCR,Transmembrane,Druggable Genome, |
| Protein Pathways | N/A |
| Molecular Weight | The human full length MRGX1 protein has a MW of 36.3kDa |
| Formulation & Reconstitution | Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions. Do not use solvents with a pH below 6.5 or those containing high concentrations of divalent metal ions (greater than 5 mM) in subsequent experiments. |
| Storage & Shipping | Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature. |
| Background | Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Potently activated by enkephalins including BAM22 (bovine adrenal medulla peptide 22) and BAM (8-22)(PubMed:26582731). BAM22 is the most potent compound and evoked a large and dose-dependent release of intracellular calcium in stably transfected cells. G(alpha)q proteins are involved in the calcium-signaling pathway. Activated by the antimalarial drug, chloroquine. May mediate chloroquine-induced itch, in a histamine-independent manner.[UniProtKB/Swiss-Prot Function] |
| Usage | Research use only |
| Conjugate | Unconjugated |
Human MRGX1 full length protein-synthetic nanodisc
Price: 10 μg $900.00 ; 50 μg $4400.00 ; 100 μg $8000.00
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