| Clone ID | 1H6 |
|---|---|
| Target | |
| Synonyms | N.A. |
| Host Species | Rabbit |
| Description | Anti-CL2A(ADC linker) antibody(1H6); Rabbit mAb |
| Delivery | In Stock |
| Uniprot ID | N.A. |
| IgG type | Rabbit IgG |
| Clonality | Monoclonal |
| Reactivity | N.A. |
| Applications | ELISA |
| Recommended Dilutions | ELISA 1:5000-10000 |
| Purification | Purified from cell culture supernatant by affinity chromatography |
| Formulation & Reconstitution | Lyophilized from sterile PBS, pH 7.4. Normally 5 % – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution. |
| Storage & Shipping | Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature. |
| Background | CL2A is a crucial component in antibody-drug conjugate (ADC) therapy, acting as a chemical linker that connects a potent DNA topoisomerase I inhibitor, SN-38, to an antibody. Representing Cysteine-Linked 2-Aminoethyl, CL2A features a complex structure with a PEG8 chain, a triazole ring, a PABC-peptide, and a maleimide group. The maleimide group binds to a cysteine residue on the antibody, facilitating targeted drug delivery. Designed to release SN-38 in acidic cancer cell environments, CL2A induces DNA damage and cell death. This versatile linker is employed in ADCs targeting various antigens like Trop-2 or HER2, tailored to specific cancer types. |
| Usage | Research use only |
| Conjugate | Unconjugated |
Anti-CL2A(ADC linker) antibody(1H6); Rabbit mAb
Price: 10μg $99.00 ; 100 μg $446.00 ; 500 μg $1340.00
Product Data
Images
Figure1. Elisa plates were pre-coated with IgG-CL2A (0.2μg/per well). Serial diluted anti-CL2A monoclonal antibody (DME101021) solutions were added, washed, and incubated with secondary antibody before Elisa reading. From above data, the EC50 for anti-CL2A monoclonal antibody binding with IgG-CL2A is 4.325ng/ml.
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