| Target | |
|---|---|
| Synonyms | BG37; TGR5; M-BAR; GPCR19; GPR131 |
| Description | Recombinant human GPBAR1 Protein with C-terminal human Fc tag |
| Delivery | In Stock |
| Uniprot ID | Q8TDU6 |
| Expression Host | HEK293 |
| Tag | C-Human Fc tag |
| Molecular Characterization | GPBAR1(Met1-Gly19) hFc(Glu99-Ala330) |
| Molecular Weight | The protein has a predicted molecular mass of 28.0 kDa after removal of the signal peptide. The apparent molecular mass of GPBAR1-hFc is approximately 25-55 kDa due to glycosylation. |
| Purity | The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining. |
| Formulation & Reconstitution | Lyophilized from sterile PBS, pH 7.4. Normally 5 % – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution. |
| Storage & Shipping | Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature. |
| Background | This gene encodes a member of the G protein-coupled receptor (GPCR) superfamily. This enzyme functions as a cell surface receptor for bile acids. Treatment of cells expressing this GPCR with bile acids induces the production of intracellular cAMP, activation of a MAP kinase signaling pathway, and internalization of the receptor. The receptor is implicated in the suppression of macrophage functions and regulation of energy homeostasis by bile acids. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008] |
| Usage | Research use only |
| Conjugate | Unconjugated |
Human GPBAR1 Protein, hFc Tag
Price:10μg $90.00 ; 50μg $320.00 ; 100μg $480.00
Product Data
Images
Figure 1. Human GPBAR1 Protein, hFc Tag on SDS-PAGE under reducing condition.
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