| Tag | C-Flag&Strep Tag |
|---|---|
| Target | |
| Synonyms | DOP, DOR, DOR1, OPRD |
| Description | Human OPRD-Strep full length protein-synthetic nanodisc |
| Delivery | 6~8weeks |
| Uniprot ID | P41143 |
| Expression Host | HEK293 |
| Protein Families | Transmembrane,Druggable Genome, |
| Protein Pathways | GPCRDB Class A Rhodopsin-like,Peptide GPCRs,Autoimmune & Inflammatory Response,G-Protein Coupled Receptors Signaling Pathway,Na2 /NF-AT Signaling Pathways, |
| Molecular Weight | The human full length OPRD-Strep protein has a MW of 40.4 kDa |
| Formulation & Reconstitution | Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions. Do not use solvents with a pH below 6.5 or those containing high concentrations of divalent metal ions (greater than 5 mM) in subsequent experiments. |
| Storage & Shipping | Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature. |
| Background | G-protein coupled receptor that functions as receptor for endogenous enkephalins and for a subset of other opioids. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain and in opiate-mediated analgesia. Plays a role in developing analgesic tolerance to morphine.[UniProtKB/Swiss-Prot Function] |
| Usage | Research use only |
| Conjugate | Unconjugated |
Human OPRD-Strep full length protein-synthetic nanodisc
Price: 10 μg $810.00 ; 50 μg $3960.00 ; 100 μg $7200.00
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