Clone ID | DMC225 |
---|---|
Target | |
Synonyms | CD360; IMD56; NILR |
Host Species | Rabbit |
Description | PE-conjugated Anti-IL21R antibody(DMC225); IgG1 Chimeric mAb |
Delivery | 3-4 weeks |
Uniprot ID | Q9HBE5 |
IgG type | Rabbit/Human Fc chimeric IgG1 |
Clonality | Monoclonal |
Reactivity | Human |
Applications | Flow Cyt |
Recommended Dilutions | Flow Cyt 1:100 |
Purification | Purified from cell culture supernatant by affinity chromatography |
Formulation & Reconstitution | Liquid,PBS with 0.05% Proclin300, 1% BSA |
Storage & Shipping | Store at 2°C-8°C for 6 months |
Background | The protein encoded by this gene is a cytokine receptor for interleukin 21 (IL21). It belongs to the type I cytokine receptors; and has been shown to form a heterodimeric receptor complex with the common gamma-chain; a receptor subunit also shared by the receptors for interleukin 2; 4; 7; 9; and 15. This receptor transduces the growth promoting signal of IL21; and is important for the proliferation and differentiation of T cells; B cells; and natural killer (NK) cells. The ligand binding of this receptor leads to the activation of multiple downstream signaling molecules; including JAK1; JAK3; STAT1; and STAT3. Knockout studies of a similar gene in mouse suggest a role for this gene in regulating immunoglobulin production. Three alternatively spliced transcript variants have been described. |
Usage | Research use only |
Conjugate | PE-conjugated |
PE-conjugated Anti-IL21R antibody(DMC225); IgG1 Chimeric mAb
Price: 100 test $550.00
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