PE-conjugated Anti-SEMA4D antibody(11G2), IgG1 Chimeric mAb

Price: 100 test $550.00

SKU: DMC101226P Category: Monoclonal antibodies

Clone ID	11G2
Target	SEMA4D
Synonyms	A8;BB18;GR3;CD100;C9orf164;CD100;SEMAJ
Host Species	Rabbit
Description	PE-conjugated Anti-SEMA4D antibody(11G2), IgG1 Chimeric mAb
Delivery	3-4 weeks
Uniprot ID	Q92854
IgG type	Rabbit/Human Fc chimeric IgG1
Clonality	Monoclonal
Reactivity	Human
Applications	Flow Cyt
Recommended Dilutions	Flow Cyt 1:100
Purification	Purified from cell culture supernatant by affinity chromatography
Formulation & Reconstitution	Liquid，PBS with 0.05% Proclin300, 1% BSA
Storage & Shipping	Store at 2°C-8°C for 6 months
Background	Cell surface receptor for PLXNB1 and PLXNB2 that plays an important role in cell-cell signaling (PubMed:20877282). Regulates GABAergic synapse development (By similarity). Promotes the development of inhibitory synapses in a PLXNB1-dependent manner (By similarity). Modulates the complexity and arborization of developing neurites in hippocampal neurons by activating PLXNB1 and interaction with PLXNB1 mediates activation of RHOA (PubMed:19788569). Promotes the migration of cerebellar granule cells (PubMed:16055703). Plays a role in the immune system; induces B-cells to aggregate and improves their viability (in vitro) (PubMed:8876214). Induces endothelial cell migration through the activation of PTK2B/PYK2, SRC, and the phosphatidylinositol 3-kinase-AKT pathway (PubMed:16055703).[UniProtKB/Swiss-Prot Function]
Usage	Research use only
Conjugate	PE-conjugated