Custom Protein Services

High-Quality, Functional Proteins for Drug Discovery

Welcome to DIMA’s Custom Protein Services – your partner in providing high-quality, functional proteins for drug discovery and research. We specialize in producing proteins that are difficult to express, purify, and characterize, including challenging druggable targets like GPCRs, ion channels, and transporters. Whether you’re researching small molecule drugs, biologics, or other therapeutic modalities, our proteins are an essential tool for advancing your work.

With over 2000 proteins successfully expressed and purified, we have developed an advanced, efficient, and scalable system for producing proteins from mammalian cell expression systems like HEK293. Our expertise and proven success with complex membrane proteins underscore our ability to deliver proteins that are not only abundant but functional for downstream applications.

Why Choose Us?

  • Expertise in Druggable Targets: We have a proven track record of producing functional proteins for some of the most challenging targets in drug discovery, including GPCRs, ion channels, transporters, and other membrane proteins.
  • Optimized Expression Systems: Using HEK293 and other mammalian cell lines, we ensure that our proteins are produced in an environment that mimics their natural state, leading to better functionality and stability.
  • Validated, Functional Proteins: Over 2000 proteins have been successfully produced, purified, and verified as functional, giving you confidence in the quality of your protein.
  • Customized Solutions: Our team works closely with you to provide tailored solutions that meet your specific needs, from protein expression to purification and functional validation.

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    Our Services

    We offer a comprehensive suite of services designed to meet the needs of researchers and biotech companies working with membrane proteins and other challenging targets. Choose the service that best fits your research goals.

    ECD (Extracellular Domain) Protein Service

    Our ECD Protein Service is designed for researchers working with single transmembrane proteins and their extracellular domains. We specialize in producing soluble extracellular regions of membrane proteins, making them easier to purify and analyze. 

    • Targeted for single-pass transmembrane proteins
    • High-purity, soluble extracellular domains
    • Ideal for structural analysis, antigen discovery, and more

    Tag Free Protein Service

    For customers requiring tag free proteins, we offer an efficient service to produce clean, native proteins without affinity tags. This service is ideal for functional studies where the presence of a tag may interfere with protein activity.

    • Tag free proteins
    • Suitable for functional assays, binding studies, and more
    • Produced with high purity and without interference from tags

    Full-Length Multipass Transmembrane Protein Service

    We offer a complete solution for full-length multipass transmembrane proteins using advanced platforms like synthetic Nanodiscs and Virus-Like Particles (VLPs). Our system is optimized for complex proteins, ensuring proper folding and functionality.

    • Full-length, up to 25-pass transmembrane proteins
    • Produced in mammalian cells (HEK293) for correct folding and modifications
    • Stable integration with Nanodiscs and VLPs
    • Over 200 successful full-length multipass proteins produced

    Protein SPR (Surface Plasmon Resonance) Service

    Surface Plasmon Resonance (SPR) is an essential tool for studying protein-protein interactions, receptor-ligand binding, and other dynamic biological processes. Our Protein SPR Service provides expertly purified proteins tailored for high-quality SPR studies, ensuring reliable data for your research.

    • Protein purification optimized for SPR applications
    • Ideal for studying protein interactions and kinetics
    • Validated for functional assays and binding studies