| Target | |
|---|---|
| Synonyms | CD16; FCG3; CD16A; FCGR3; IGFR3; IMD20; FCR-10; FCRIII; CD16-II; FCGRIII; FCRIIIA; FcGRIIIA |
| Description | Recombinant Cynomolgus FCGR3A protein with C-terminal human Fc tag |
| Delivery | In Stock |
| Uniprot ID | Q8SPW2 |
| Expression Host | HEK293 |
| Tag | C-Human Fc tag |
| Molecular Characterization | FCGR3A(Gly17-Gly206) hFc(Glu99-Ala330) |
| Molecular Weight | The protein has a predicted molecular mass of 47.8 kDa after removal of the signal peptide. The apparent molecular mass of cFCGR3A-hFc is approximately 55-70 kDa due to glycosylation. |
| Purity | The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining. |
| Formulation & Reconstitution | Lyophilized from sterile PBS, pH 7.4. Normally 5 % – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution. |
| Storage & Shipping | Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature. |
| Background | This gene encodes a receptor for the Fc portion of immunoglobulin G, and it is involved in the removal of antigen-antibody complexes from the circulation, as well as other responses, including antibody dependent cellular mediated cytotoxicity and antibody dependent enhancement of virus infections. This gene (FCGR3A) is highly similar to another nearby gene (FCGR3B) located on chromosome 1. The receptor encoded by this gene is expressed on natural killer (NK) cells as an integral membrane glycoprotein anchored through a transmembrane peptide, whereas FCGR3B is expressed on polymorphonuclear neutrophils (PMN) where the receptor is anchored through a phosphatidylinositol (PI) linkage. Mutations in this gene are associated with immunodeficiency 20, and have been linked to susceptibility to recurrent viral infections, susceptibility to systemic lupus erythematosus, and alloimmune neonatal neutropenia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2020] |
| Usage | Research use only |
| Conjugate | Unconjugated |
Cynomolgus FCGR3A Protein, hFc Tag
Price: 10μg $72.00 ; 50μg $274.00 ; 100μg $411.00
Product Data
Images
Figure 1. Cynomolgus FCGR3A Protein, hFc Tag on SDS-PAGE under reducing condition.
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