| Target | |
|---|---|
| Synonyms | LDS4; G-TSF; TGF-beta2 |
| Description | Recombinant human TGFB2(21-414) Protein with N-terminal 10×His tag |
| Delivery | In Stock |
| Uniprot ID | P61812 |
| Expression Host | HEK293 |
| Tag | N-10×His tag |
| Molecular Characterization | 10×His tag TGFB2(Leu21-Ser414) |
| Molecular Weight | The protein has a predicted molecular mass of 46.9 kDa after removal of the signal peptide. |
| Purity | The purity of the protein is greater than 85% as determined by SDS-PAGE and Coomassie blue staining. |
| Formulation & Reconstitution | Lyophilized from sterile PBS, pH 7.4. Normally 5 % – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution. |
| Storage & Shipping | Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature. |
| Background | This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate a latency-associated peptide (LAP) and a mature peptide, and is found in either a latent form composed of a mature peptide homodimer, a LAP homodimer, and a latent TGF-beta binding protein, or in an active form consisting solely of the mature peptide homodimer. The mature peptide may also form heterodimers with other TGF-beta family members. Disruption of the TGF-beta/SMAD pathway has been implicated in a variety of human cancers. A chromosomal translocation that includes this gene is associated with Peters' anomaly, a congenital defect of the anterior chamber of the eye. Mutations in this gene may be associated with Loeys-Dietz syndrome. This gene encodes multiple isoforms that may undergo similar proteolytic processing. [provided by RefSeq, Aug 2016] |
| Usage | Research use only |
| Conjugate | Unconjugated |
Human TGFB2(21-414) Protein, His Tag
Price:10μg $72.00; 50μg $274.00 ; 100 μg $411.00
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Figure 1. Human TGFB2(21-414) Protein, His Tag on SDS-PAGE under reducing condition.
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SKU: PME101015 Target: TGFB2
Price:10μg $72.00; 50μg $274.00 ; 100 μg $411.00