The Claudin (CLDN) family comprises key transmembrane proteins that form tight junctions between adjacent cells. Several members—such as CLDN18.2, CLDN6, and CLDN9—are overexpressed in a variety of tumors and have emerged as important targets for precision therapies, including monoclonal antibodies, antibody–drug conjugates (ADCs), and CAR-T cell therapies. Studies have shown that targeting CLDN proteins holds therapeutic potential for gastric cancer, ovarian cancer, liver cancer, inflammatory bowel disease, and neurological disorders. The CLDN family is rapidly becoming a prominent group among membrane protein drug targets. To date, 27 CLDN members (CLDN1–CLDN27) have been identified. Each exhibits distinct tissue-specific expression patterns and plays critical roles under both physiological and pathological conditions.
CLDN Targets in Drug Development
Membrane proteins have long been considered challenging targets due to their complex structures, tendency to aggregate, and sensitivity to environmental conditions. By combining Nanodisc technology with a HEK293 expression system, DIMA stably incorporates full-length CLDN proteins into a near-physiological lipid environment. This approach preserves native conformation, biological functionality, and binding activity, ensuring more reliable and reproducible results for your research.
As a thank-you to our valued customers, DIMA is offering an instant $450 discount on the 10 µg size CLDN Nanodisc protein. Stock is limited—first come, first served!
Promotional Product List：
Terms & Conditions:
Promotion Period: April 20 – May 20, 2025.
Eligibility: Available to end users only. Not valid for resellers or distributors.
Promo Code: Use CLDN2025 when placing an order via online chat, email, or phone to receive the discount.
Stock Availability: Limited stock available. Promotion ends when supplies run out.
Order Method: Orders must be placed directly with DIMA Biotech via online chat, email (info@dimabio.com / orders@dimabio.com), or phone (+1 978-912-0878).
Non-Transferable: Cannot be combined with other promotions or discounts.
Returns and Exchanges: Discount does not apply to returns, exchanges, or canceled orders.
Right to Modify: DIMA Biotech reserves the right to modify or cancel this promotion at any time.
Conditions: Applicable only to 10 µg size of CLDN Nanodisc protein products. A maximum of 2 units per catalog number can be purchased (multiple catalog numbers allowed).