| Clone ID | DM143 |
|---|---|
| Target | |
| Synonyms | BAFFR;TNFRSF13C;BAFF-R;BROMIX;CD268;CVID4;prolixin |
| Host Species | Rabbit |
| Description | Anti-BAFF-R antibody(DM143); Rabbit mAb |
| Delivery | In Stock |
| Uniprot ID | Q96RJ3 |
| IgG type | Rabbit IgG |
| Clonality | Monoclonal |
| Reactivity | Human |
| Applications | ELISA; Flow Cyt; IHC |
| Recommended Dilutions | ELISA 1:5000-10000; Flow Cyt 1:100; IHC 1:100 |
| Purification | Purified from cell culture supernatant by affinity chromatography |
| Formulation & Reconstitution | Lyophilized from sterile PBS, pH 7.4. Normally 5 % – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution. |
| Storage & Shipping | Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature. |
| Background | B cell-activating factor (BAFF) enhances B-cell survival in vitro and is a regulator of the peripheral B-cell population. Overexpression of Baff in mice results in mature B-cell hyperplasia and symptoms of systemic lupus erythematosus (SLE). Also; some SLE patients have increased levels of BAFF in serum. Therefore; it has been proposed that abnormally high levels of BAFF may contribute to the pathogenesis of autoimmune diseases by enhancing the survival of autoreactive B cells. The protein encoded by this gene is a receptor for BAFF and is a type III transmembrane protein containing a single extracellular cysteine-rich domain. It is thought that this receptor is the principal receptor required for BAFF-mediated mature B-cell survival. |
| Usage | Research use only |
| Conjugate | Unconjugated |
Anti-BAFF-R antibody(DM143); Rabbit mAb
Price: 10μg $99.00 ; 100 μg $446.00 ; 500 μg $1340.00
Product Data
Images
Figure 1. ELISA plate pre-coated by 1 μg/ml (100 μl/well) Human BAFFR protein, mFc tagged protein PME100044 can bind Rabbit anti-BAFFR monoclonal antibody (clone: DM143) in a linear range of 0.8-50
Figure 2. Flow cytometry analysis with Anti-BAFFR (DM143) on Expi293 cells transfected with human BAFFR (Blue histogram) or Expi293 transfected with irrelevant protein (Red histogram).
Figure 3. A. DME100143 at 10µg/ml staining BAFF-R in Raji cells by IHC (SKU# DME100143);B. DME100143 at 10µg/ml staining BAFF-R in human tonsil tissue by IHC (SKU# DME100143)
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