| Target | |
|---|---|
| Synonyms | CMT1F;CMT2E;CMTDIG;NF-L;NF68;NFL;PPP1R110 |
| Description | Recombinant Human NEFL with C-terminal human Fc tag |
| Delivery | In Stock |
| Uniprot ID | P07196 |
| Expression Host | HEK293 |
| Tag | C-Human Fc Tag |
| Molecular Characterization | NEFL(Ser2-Asp543) hFc(Glu99-Ala330) |
| Molecular Weight | The protein has a predicted molecular mass of 87.5 kDa after removal of the signal peptide. The apparent molecular mass of NEFL-hFc is approximately 35-55 kDa due to glycosylation. |
| Purity | The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining. |
| Formulation & Reconstitution | Lyophilized from sterile PBS, pH 7.4. Normally 5 % – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution. |
| Storage & Shipping | Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature. |
| Background | Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and they functionally maintain the neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the light chain neurofilament protein. Mutations in this gene cause Charcot-Marie-Tooth disease types 1F (CMT1F) and 2E (CMT2E), disorders of the peripheral nervous system that are characterized by distinct neuropathies. A pseudogene has been identified on chromosome Y. [provided by RefSeq, Oct 2008] |
| Usage | Research use only |
| Conjugate | Unconjugated |
Human NEFL Protein, hFc Tag
Price: 10μg $82.00; 50μg $320.00 ; 100 μg $480.00
Product Data
Images
Figure 1. Human NEFL Protein, hFc Tag on SDS-PAGE under reducing condition.
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