| Clone ID | DMC674 |
|---|---|
| Target | |
| Synonyms | DHLAG; HLADG; Ia-GAMMA; II; p33 |
| Host Species | Rabbit |
| Description | Anti-CD74 antibody(DMC674); IgG1 Chimeric mAb |
| Delivery | In Stock |
| Uniprot ID | P04233 |
| IgG type | Rabbit/Human Fc chimeric IgG1 |
| Clonality | Monoclonal |
| Reactivity | Human |
| Applications | Flow Cyt |
| Recommended Dilutions | Flow Cyt 1:100 |
| Purification | Purified from cell culture supernatant by affinity chromatography |
| Formulation & Reconstitution | Lyophilized from sterile PBS, pH 7.4. Normally 5 % – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution. |
| Storage & Shipping | Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature. |
| Background | The protein encoded by this gene associates with class II major histocompatibility complex (MHC) and is an important chaperone that regulates antigen presentation for immune response. It also serves as cell surface receptor for the cytokine macrophage migration inhibitory factor (MIF) which; when bound to the encoded protein; initiates survival pathways and cell proliferation. This protein also interacts with amyloid precursor protein (APP) and suppresses the production of amyloid beta (Abeta). Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq; Aug 2011] |
| Usage | Research use only |
| Conjugate | Unconjugated |
Anti-CD74 antibody(DMC674), IgG1 Chimeric mAb
Price: 10μg $99.00 ; 100 μg $446.00 ; 500 μg $1340.00
Product Data
Images
Figure 1. Flow cytometry analysis with Anti-CD74(DMC674) on Expi293 cells transfected with human CD74(Blue histogram) or Expi293 transfected with irrelevant protein (Red histogram).
Figure 2. Flow cytometry analysis of antigen binding of anti-human CD74 mAb(DMC100674).
(A) DMC100674 does not bind to 293T cells that do not express CD74.
(B) A clear peak shift of DMC100674 was seen compared to the control when incubated with CD74-expressing Raji cells, indicating strong binding of DMC100674 to CD74. Antibodies were incubated at 5 μg/mL.
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