Tumor-Associated Calcium Signal Transducer 2 (TROP2), also known as TACSTD2 and EGP-1, is a surface antigen found in numerous solid tumors. It has become a pivotal target for pharmaceutical giants spurring a race in drug development in the world. Currently, TROP2-targeting biopharmaceuticals are predominantly concentrated in the Antibody-Drug Conjugate (ADC). Based on incomplete statistics, there are 11 TROP2-targeting […]
Antibody-drug conjugates (ADCs) represent a promising class of targeted therapies in the fight against cancer. These innovative therapies aim to deliver small-molecule chemotherapy agents directly to cancer cells while sparing healthy ones. Since the approval of MYLOTARG in 2000, ADCs have become a vital category in the realm of cancer-targeted treatments, consisting of three key […]
In 2012, a young girl named Emily Whitehead, suffering from acute lymphoblastic leukemia, became the first child to undergo second-generation CD19 CAR-T cell therapy by Dr. Carl June, a scientist in Pennsylvania. Her successful treatment marked a historic milestone in the world of medicine. It brought “CAR-T cell immunotherapy,” a revolutionary approach in the fight […]
In 1986, the world’s first monoclonal therapeutic drug, Orthoclone (OKT3), was approved by the FDA for its use in preventing rejection reactions during organ transplantation. Since then, antibody drugs have started gaining traction and incited an increasing number of research in this area. By the end of January 2023, the FDA has approved 119 antibody […]
Human carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5), initially discovered in colon cancer by Gold and Freeman in 1965 [1] [2], has long served as a pivotal tumor marker for clinical detection and diagnosis of colorectal cancer. Recent advancements in CEACAM5 research have unveiled its potential as a target for developing novel cancer therapeutics. Notably, […]
In June 2023, BioNTech presented the first human trial data of BNT211 at the American Society of Clinical Oncology (ASCO). BNT211 is a CLDN-6-targeting CAR-T cell therapy in combination with a CLDN6-encoding mRNA vaccine (CARVac). mRNA vaccines stimulate the expansion of CAR-T cells in the patients’ body by inducing the expression of CLDN6 on the surface of antigen-presenting cells, […]
In 2023…… On May 12th, LaNova announced that AstraZeneca will receive an exclusive global license for LM-305’s research, development, and commercialization. LM-305 is a new pre-clinical stage antibody-drug conjugate (ADC) targeting GPRC5D. LaNova Medicines will receive an immediate payment of $55 million and $545 million in additional development and commercial milestone payments. On May 19th, the clinical trial application for OriCAR-017 […]
The transient receptor potential ankyrin 1 (TRPA1) is a non-selective cation channel that allows the passage of Ca2+, thereby increasing intracellular Ca2+ levels. TRPA1 has garnered significant attention due to its ability to respond to various environmental stimuli and its involvement in pain perception and inflammatory processes. As of now, there are approximately 22 drugs […]
