Membrane proteins, especially multipass transmembrane proteins like GPCRs, ion channels, and transporters, are at the forefront of drug discovery but have long been considered “unapproachable” due to the challenges in producing them in their full-length, active forms. At DIMA, we harness cutting-edge technology to overcome these challenges and offer reliable, high-quality preparation of full-length membrane proteins. Whether it’s GPCRs, ion channels, or transporters, our state-of-the-art systems—including MNP, VLP, and Nanodisc—ensure the proper folding and functionality of these complex targets. We provide the tools to unlock their potential, accelerating your research and advancing the development of next-generation therapeutics.

Service Highlights:

Unmatched Expertise

With 300+ successful full-length, multipass membrane proteins, including proteins with up to 24 passes, we have unmatched experience with complex targets.

 Stable & Active Proteins

Our proteins stay stable and active, even when shipped at room temperature for several days. View our testing data for more details.

Custom Solutions for Your Needs

Whether for structural studies, functional testing, or drug screening, we offer flexible, high-quality solutions tailored to your specific project.

Workflow

ProteinServiceWebpage-protein service workflow

Cases Studies

Human CLDN18.2 full length protein-VLP (Cat# FLP100006) 4 pass transmembrane protein

elisa-FLP100006 CLDN18.2 Fig.1 Elisa 1

Flagged tagged human CLDN18.2 VLP (FLP100006) can bind to Anti-CLDN18.2 monoclonal antibody (Zolbetuximab; IMAB362) and the EC50 is 15.37ng/ml.

fc-FLP100006 CLDN18.2 Fig.2 FC 1

FACS analysis of CLDN18.2 VLP
A. CLDN18.2 VLP stained with Goat anti-human IgG Fc-PE secondary antibody.
B. Control VLP stained anti-CLDN18.2 antibody (Zolbetuximab; IMAB362) followed by Goat anti-human IgG Fc-PE secondary antibody.
C. CLDN18.2 VLP stained with anti-BCMA antibody (irrelevant antibody) followed by Goat anti-human IgG Fc-PE secondary antibody.
D. CLDN18.2 VLP stained with anti-CLDN18.2 antibody (Zolbetuximab; IMAB362) followed by Goat anti-human IgG Fc-PE secondary antibody.

Human CB1 full length protein-MNP (Cat# FLP100009) 7 pass transmembrane protein

elisa-FLP100009 CB1 Fig.1 Elisa 1

Flagged tagged human CB1 MNP (FLP100009) can bind to anti-CB1 monoclonal antibody (DME100144) and the EC50 is 439.6ng/ml.

fc-FLP100009 CB1 Fig.2 FC 1

FACS analysis of CB1 MNP
A. CB1 MNP stained with Goat anti-human IgG 488 secondary antibody.
B. Control MNP stained with anti-CB1 antibody (BME100049) followed by Goat anti-human IgG 488 secondary antibody.
C. CB1 MNP stained with anti-CCR8 antibody (irrelevant antibody) followed by Goat anti-human IgG 488 secondary antibody.
D. CB1 MNP stained anti-CB1 antibody (BME100049) followed by Goat anti-human IgG 488 secondary antibody.

Human CLDN18.2 full length protein-synthetic nanodisc (Cat# FLP100014) 4 pass transmembrane protein

page-FLP100014 CLDN18.2 Fig.2 SDS PAGE 1

Human CLDN18.2-Nanodisc, Flag Tag on SDS-PAGE

elisa-FLP100014 CLDN18.2 Fig.1 Elisa 1

Human CLDN18.2-Nanodisc (0.2μg/per well) binds to anti- CLDN18.2 mAb (Cat. No. BME100075) (EC50 593.6ng/ml).

SPR-FLP100014 CLDN18.2 Fig.3 SPR 1

Human CLDN18.2-Nanodisc can bind Anti-CLDN18.2 antibody (BME100075) with an affinity constant of 1.619 nM as determined in a SPR assay.

Human MDR-1 full length protein-synthetic nanodisc (Cat# FLP100029) 12 pass transmembrane protein

Human MDR-1-Nanodisc, Flag Tag on SDS-PAGE

Human MDR-1-Nanodisc, Flag Tag on SDS-PAGE

ELISA assay to evaluate MDR-1-Nanodisc

MDR-1-Nanodisc (FLP100029) can bind anti-Flag monoclonal antibody and the EC50 is 6.883ng/ml.

Human GPRC5D full length protein-synthetic nanodisc (Cat# FLP100011) 7 pass transmembrane protein

Human GPRC5D-Nanodisc, Flag Tag on SDS-PAGE

Human GPRC5D-Nanodisc, Flag Tag on SDS-PAGE

GPRC5D-Nanodisc (FLP100011) can bind anti-GPRC5D mAb (DME100090) and the EC50 is 32.86ng/ml.

Human CD63 full length protein-synthetic nanodisc (Cat#: FLP100030)

High Activity

ELISA

pages-Full length Membrane Proteins High Activity High Stability 4

High Stability

Lyophilization test

pages-Full length Membrane Proteins High Activity High Stability 5

Accelerated Test (Lyophilized Powder)

pages-Full length Membrane Proteins High Activity High Stability 6