| Clone ID | 1B5 |
|---|---|
| Target | |
| Synonyms | CEACAM-5;CD66e;CEA;Meconium antigen 100 |
| Host Species | Rabbit |
| Description | Anti-CEACAM5 antibody(1B5), IgG1 Chimeric mAb |
| Delivery | In Stock |
| Uniprot ID | P06731 |
| IgG type | Rabbit/Human Fc chimeric IgG1 |
| Clonality | Monoclonal |
| Reactivity | Human |
| Applications | WB |
| Recommended Dilutions | WB 1:1000 |
| Purification | Purified from cell culture supernatant by affinity chromatography |
| Formulation & Reconstitution | Lyophilized from sterile PBS, pH 7.4. Normally 5 % – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution. |
| Storage & Shipping | Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature. |
| Background | This gene encodes a cell surface glycoprotein that represents the founding member of the carcinoembryonic antigen (CEA) family of proteins. The encoded protein is used as a clinical biomarker for gastrointestinal cancers and may promote tumor development through its role as a cell adhesion molecule. Additionally, the encoded protein may regulate differentiation, apoptosis, and cell polarity. This gene is present in a CEA family gene cluster on chromosome 19. Alternative splicing results in multiple transcript variants. |
| Usage | Research use only |
| Conjugate | Unconjugated |
Anti-CEACAM5 antibody(1B5), IgG1 Chimeric mAb
Price: 10μg $99.00 ; 100 μg $446.00 ; 500 μg $1340.00
Product Data
Images
Figure 1.Anti-CEACAM5 antibody (SKU# DMC100120) at 1/1000 dilution
Lane : HT55, whole cell lysate
Secondary : Goat Anti-Rabbit IgG H&L (HRP) at 1/5000 dilution
Predicted band size: 76kDa
Observed band size: 50，250 kDa
Figure 2. Flow cytometry analysis of antigen binding of anti-human CEACAM5 mAb(DMC100120).
(A) DMC100120 does not bind to CHO-S cells that do not express CEACAM5.
(B) A clear peak shift of DMC100120 was seen compared to the control when incubated with CEACAM5-expressing MKN45 cells, indicating strong binding of DMC100120 to CEACAM5. Antibodies were incubated at 5 μg/mL.
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