| Clone ID | DMC480 |
|---|---|
| Target | |
| Synonyms | CAK; EDDR1; NEP; NTRK4; PTK3A; RTK6; TRKE; MCK-10; HGK2; CD167a |
| Host Species | Rabbit |
| Description | Anti-DDR1 antibody(DMC480); IgG1 Chimeric mAb |
| Delivery | In Stock |
| Uniprot ID | Q08345 |
| IgG type | Rabbit/Human Fc chimeric IgG1 |
| Clonality | Monoclonal |
| Reactivity | Human |
| Applications | Flow Cyt |
| Recommended Dilutions | Flow Cyt 1:100 |
| Purification | Purified from cell culture supernatant by affinity chromatography |
| Formulation & Reconstitution | Lyophilized from sterile PBS, pH 7.4. Normally 5 % – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution. |
| Storage & Shipping | Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature. |
| Background | Receptor tyrosine kinases play a key role in the communication of cells with their microenvironment. These kinases are involved in the regulation of cell growth; differentiation and metabolism. The protein encoded by this gene belongs to a subfamily of tyrosine kinase receptors with homology to Dictyostelium discoideum protein discoidin I in their extracellular domain; and that are activated by various types of collagen. Expression of this protein is restricted to epithelial cells; particularly in the kidney; lung; gastrointestinal tract; and brain. In addition; it has been shown to be significantly overexpressed in several human tumors. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq; Feb 2011] |
| Usage | Research use only |
| Conjugate | Unconjugated |
Anti-DDR1 antibody(DMC480); IgG1 Chimeric mAb
Price: 10μg $99.00 ; 100 μg $446.00 ; 500 μg $1340.00
Product Data
Images
Figure 1. Flow cytometry analysis with Anti-DDR1 (DMC480) on Expi293 cells transfected with human DDR1 (Blue histogram) or Expi293 transfected with irrelevant protein (Red histogram).
Figure 2. Flow cytometry analysis of antigen binding of anti-human DDR1 mAb(DMC100480).
(A) DMC100480 does not bind to jurkat cells that do not express DDR1.
(B) A clear peak shift of DMC100480 was seen compared to the control when incubated with DDR1-expressing SNU-5 cells, indicating strong binding of DMC100480 to DDR1. Antibodies were incubated at 5 μg/mL.
Figure 3. Flow cytometry analysis of antigen binding of anti-human DDR1 mAb(DMC100480).
(A) DMC100480 does not bind to jurkat cells that do not express DDR1.
(B) A clear peak shift of DMC100480 was seen compared to the control when incubated with DDR1-expressing MCF-7 cells, indicating strong binding of DMC100480 to DDR1. Antibodies were incubated at 5 μg/mL.
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