| Clone ID | DMC460 |
|---|---|
| Target | |
| Synonyms | CD334; JTK2; TKF |
| Host Species | Rabbit |
| Description | Anti-FGFR4 antibody(DMC460); IgG1 Chimeric mAb |
| Delivery | In Stock |
| Uniprot ID | P22455 |
| IgG type | Rabbit/Human Fc chimeric IgG1 |
| Clonality | Monoclonal |
| Reactivity | Human |
| Applications | Flow Cyt |
| Recommended Dilutions | Flow Cyt 1:100 |
| Purification | Purified from cell culture supernatant by affinity chromatography |
| Formulation & Reconstitution | Lyophilized from sterile PBS, pH 7.4. Normally 5 % – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution. |
| Storage & Shipping | Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature. |
| Background | The protein encoded by this gene is a tyrosine kinase and cell surface receptor for fibroblast growth factors. The encoded protein is involved in the regulation of several pathways; including cell proliferation; cell differentiation; cell migration; lipid metabolism; bile acid biosynthesis; vitamin D metabolism; glucose uptake; and phosphate homeostasis. This protein consists of an extracellular region; composed of three immunoglobulin-like domains; a single hydrophobic membrane-spanning segment; and a cytoplasmic tyrosine kinase domain. The extracellular portion interacts with fibroblast growth factors; setting in motion a cascade of downstream signals; ultimately influencing mitogenesis and differentiation. [provided by RefSeq; Aug 2017] |
| Usage | Research use only |
| Conjugate | Unconjugated |
Anti-FGFR4 antibody(DMC460), IgG1 Chimeric mAb
Price: 10μg $99.00 ; 100 μg $446.00 ; 500 μg $1340.00
Product Data
Images
Figure 1. Flow cytometry analysis with Anti-FGFR4 (DMC460) on Expi293 cells transfected with human FGFR4 (Blue histogram) or Expi293 transfected with irrelevant protein (Red histogram).
Figure 2. Flow cytometry analysis of antigen binding of anti-human FGFR4 mAb(DMC100460).
(A) DMC100460 does not bind to SiHa cells that do not express FGFR4.
(B) A clear peak shift of DMC100460 was seen compared to the control when incubated with FGFR4-expressing Huh7 cells, indicating strong binding of DMC100460 to FGFR4. Antibodies were incubated at 5 μg/mL.
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