| Clone ID | 151A5 |
|---|---|
| Target | |
| Synonyms | ROR1;NTRKR1 |
| Host Species | Rabbit |
| Description | Anti-ROR1 antibody(151A5), IgG1 Chimeric mAb |
| Delivery | In Stock |
| Uniprot ID | Q01973 |
| IgG type | Rabbit/Human Fc chimeric IgG1 |
| Clonality | Monoclonal |
| Reactivity | Human |
| Applications | WB |
| Recommended Dilutions | WB 1/1000 |
| Purification | Purified from cell culture supernatant by affinity chromatography |
| Formulation & Reconstitution | Lyophilized from sterile PBS, pH 7.4. Normally 5 % – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution. |
| Storage & Shipping | Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature. |
| Background | This gene encodes a receptor tyrosine kinase-like orphan receptor that modulates neurite growth in the central nervous system. The encoded protein is a glycosylated type I membrane protein that belongs to the ROR subfamily of cell surface receptors. It is a pseudokinase that lacks catalytic activity and may interact with the non-canonical Wnt signalling pathway. This gene is highly expressed during early embryonic development but expressed at very low levels in adult tissues. Increased expression of this gene is associated with B-cell chronic lymphocytic leukaemia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2012] |
| Usage | Research use only；All DIMA recombinant antibodies are genuinely generated by DIMA Biotech. They are all under patent application. Any protein sequencing or reverse engineering attempt is prohibited. We are actively scrutinizing all patent application to ensure no IP infringement. |
| Conjugate | Unconjugated |
Anti-ROR1 antibody(151A5), IgG1 Chimeric mAb
Price: 10μg $99.00 ; 100 μg $446.00 ; 500 μg $1340.00
Product Data
Images
Figure 1.Anti-ROR1 antibody (SKU# DMC100228) at 1/1000 dilution
Lane : 293T-ROR1, whole cell lysate
Secondary : Goat Anti-Rabbit IgG H&L (HRP) at 1/5000 dilution
Predicted band size: 104 kDa
Observed band size: 110 kDa
Figure 2. Flow cytometry analysis of antigen binding of anti-human ROR1 mAb(DMC100228).
(A) DMC100228 does not bind to CHO-S cells that do not express ROR1.
(B) A clear peak shift of DMC100228 was seen compared to the control when incubated with ROR1-expressing AGS cells, indicating strong binding of DMC100228 to ROR1. Antibodies were incubated at 5 μg/mL.
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