| Clone ID | 151A5 |
|---|---|
| Target | |
| Synonyms | ROR1;NTRKR1 |
| Host Species | Rabbit |
| Description | Anti-ROR1 antibody(151A5), IgG1 Chimeric mAb |
| Delivery | In Stock |
| Uniprot ID | Q01973 |
| IgG type | Rabbit/Human Fc chimeric IgG1 |
| Clonality | Monoclonal |
| Reactivity | Human |
| Applications | WB |
| Recommended Dilutions | WB 1/1000 |
| Purification | Purified from cell culture supernatant by affinity chromatography |
| Formulation & Reconstitution | Lyophilized from sterile PBS, pH 7.4. Normally 5 % – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution. |
| Storage & Shipping | Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature. |
| Background | This gene encodes a receptor tyrosine kinase-like orphan receptor that modulates neurite growth in the central nervous system. The encoded protein is a glycosylated type I membrane protein that belongs to the ROR subfamily of cell surface receptors. It is a pseudokinase that lacks catalytic activity and may interact with the non-canonical Wnt signalling pathway. This gene is highly expressed during early embryonic development but expressed at very low levels in adult tissues. Increased expression of this gene is associated with B-cell chronic lymphocytic leukaemia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2012] |
| Usage | Research use only |
| Conjugate | Unconjugated |
Anti-ROR1 antibody(151A5), IgG1 Chimeric mAb
Price: 10μg $99.00 ; 100 μg $446.00 ; 500 μg $1340.00
Product Data
Images
Figure 1.Anti-ROR1 antibody (SKU# DMC100228) at 1/1000 dilution
Lane : 293T-ROR1, whole cell lysate
Secondary : Goat Anti-Rabbit IgG H&L (HRP) at 1/5000 dilution
Predicted band size: 104 kDa
Observed band size: 110 kDa
Figure 2. Flow cytometry analysis of antigen binding of anti-human ROR1 mAb(DMC100228).
(A) DMC100228 does not bind to CHO-S cells that do not express ROR1.
(B) A clear peak shift of DMC100228 was seen compared to the control when incubated with ROR1-expressing AGS cells, indicating strong binding of DMC100228 to ROR1. Antibodies were incubated at 5 μg/mL.
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