| Clone ID | DMC467 |
|---|---|
| Target | |
| Synonyms | AAT3; FAA3; LDS1B; LDS2; LDS2B; MFS2; RIIC; TAAD2; TBR-ii; TBRII; TGFbeta-RII; TGFR-2 |
| Host Species | Rabbit |
| Description | Anti-TGFBR2 antibody(DMC467); IgG1 Chimeric mAb |
| Delivery | In Stock |
| Uniprot ID | P37173 |
| IgG type | Rabbit/Human Fc chimeric IgG1 |
| Clonality | Monoclonal |
| Reactivity | Human |
| Applications | Flow Cyt |
| Recommended Dilutions | Flow Cyt 1:100 |
| Purification | Purified from cell culture supernatant by affinity chromatography |
| Formulation & Reconstitution | Lyophilized from sterile PBS, pH 7.4. Normally 5 % – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution. |
| Storage & Shipping | Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature. |
| Background | The protein encoded by this gene is a transmembrane protein that has a protein kinase domain; forms a heterodimeric complex with TGF-beta receptor type-1; and binds TGF-beta. This receptor:ligand complex phosphorylates proteins; which then enter the nucleus and regulate the transcription of genes related to cell proliferation; cell cycle arrest; wound healing; immunosuppression; and tumorigenesis. Mutations in this gene have been associated with Marfan Syndrome; Loeys-Deitz Aortic Aneurysm Syndrome; and the development of various types of tumors. Alternatively spliced transcript variants encoding different isoforms have been characterized. [provided by RefSeq; Aug 2017] |
| Usage | Research use only |
| Conjugate | Unconjugated |
Anti-TGFBR2 antibody(DMC467); IgG1 Chimeric mAb
Price: 10μg $99.00 ; 100 μg $446.00 ; 500 μg $1340.00
Product Data
Images
Figure 1. Flow cytometry analysis with Anti-TGFBR2 (DMC467) on Expi293 cells transfected with human TGFBR2 (Blue histogram) or Expi293 transfected with irrelevant protein (Red histogram).
Figure 2. Flow cytometry analysis of antigen binding of anti-human TGFBR2 mAb(DMC100467).
(A) DMC100467 does not bind to CHO-S cells that do not express TGFBR2.
(B) A clear peak shift of DMC100467 was seen compared to the control when incubated with TGFBR2-expressing hepG2 cells, indicating strong binding of DMC100467 to TGFBR2. Antibodies were incubated at 5 μg/ml.
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