| Clone ID | DMC223 |
|---|---|
| Target | |
| Synonyms | PLOSL2; TREM-2; Trem2a; Trem2b; Trem2c |
| Host Species | Rabbit |
| Description | Anti-TREM2 antibody(DMC223); IgG1 Chimeric mAb |
| Delivery | In Stock |
| Uniprot ID | Q9NZC2 |
| IgG type | Rabbit/Human Fc chimeric IgG1 |
| Clonality | Monoclonal |
| Reactivity | Human |
| Applications | ELISA; Flow Cyt |
| Recommended Dilutions | ELISA 1:5000-10000; Flow Cyt 1:100 |
| Purification | Purified from cell culture supernatant by affinity chromatography |
| Formulation & Reconstitution | Lyophilized from sterile PBS, pH 7.4. Normally 5 % – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution. |
| Storage & Shipping | Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature. |
| Background | This gene encodes a membrane protein that forms a receptor signaling complex with the TYRO protein tyrosine kinase binding protein. The encoded protein functions in immune response and may be involved in chronic inflammation by triggering the production of constitutive inflammatory cytokines. Defects in this gene are a cause of polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL). Alternative splicing results in multiple transcript variants encoding different isoforms. |
| Usage | Research use only |
| Conjugate | Unconjugated |
Anti-TREM2 antibody(DMC223); IgG1 Chimeric mAb
Price: 10μg $99.00 ; 100 μg $446.00 ; 500 μg $1340.00
Product Data
Images
Figure 1. Flow cytometry analysis with Anti-TREM2 (DMC223) on Expi293 cells transfected with human TREM2 (Blue histogram) or Expi293 transfected with irrelevant protein (Red histogram).
Figure 2. Flow cytometry analysis of antigen binding of anti-human TREM2 mAb(DMC100223).
(A) DMC100223 does not bind to CHO-S cells that do not express TREM2.
(B) A clear peak shift of DMC100223 was seen compared to the control when incubated with TREM2-expressing THP-1 cells, indicating strong binding of DMC100223 to TREM2. Antibodies were incubated at 5 μg/mL.
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