| Target | |
|---|---|
| Synonyms | BG;B2G1;B2GP1 |
| Description | Recombinant human APOH Protein with C-terminal 6×His tag |
| Delivery | In Stock |
| Uniprot ID | P02749 |
| Expression Host | HEK293 |
| Tag | C-6×His Tag |
| Molecular Characterization | APOH(Gly20-Cys345) 6×His tag |
| Molecular Weight | The protein has a predicted molecular mass of 37.1 kDa after removal of the signal peptide. The apparent molecular mass of APOH-His is approximately 35-70 kDa due to glycosylation. |
| Purity | The purity of the protein is greater than 85% as determined by SDS-PAGE and Coomassie blue staining. |
| Formulation & Reconstitution | Lyophilized from sterile PBS, pH 7.4. Normally 5 % – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution. |
| Storage & Shipping | Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature. |
| Background | Apolipoprotein H, also known as beta-2-glycoprotein I, is a component of circulating plasma lipoproteins. It has been implicated in a variety of physiologic pathways including lipoprotein metabolism, coagulation, hemostasis, and the production of antiphospholipid autoantibodies. APOH may be a required cofactor for anionic phospholipid binding by the antiphospholipid autoantibodies found in sera of many patients with lupus and primary antiphospholipid syndrome (APS). The anti-beta (2) glycoprotein I antibodies from APS patients, mediate inhibition of activated protein C which has anticoagulant properties. Because beta-2-GPI is the main autoantigen in patients with APS, the disruption of this pathway by autoantibodies may be an important mechanism for thrombosis in patients with APS.[provided by RefSeq, Dec 2019] |
| Usage | Research use only |
| Conjugate | Unconjugated |
Human APOH Protein, His Tag
Price: 10μg $70.00; 50μg $244.00 ; 100μg $367.00
Product Data
Images
Figure 1. Human APOH Protein, His Tag on SDS-PAGE under reducing condition.
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