| Tag | C-Flag Tag |
|---|---|
| Target | |
| Synonyms | ARB, BEST, BMD, Best1V1Delta2, RP50, TU15B, VMD2 |
| Description | Human BEST1 full length protein-synthetic nanodisc |
| Delivery | 6~8weeks |
| Uniprot ID | O76090 |
| Expression Host | HEK293 |
| Protein Families | Ion Channels: Other |
| Protein Pathways | N/A |
| Molecular Weight | The human full length BEST1 protein has a MW of 67.7kDa |
| Formulation & Reconstitution | Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions. Do not use solvents with a pH below 6.5 or those containing high concentrations of divalent metal ions (greater than 5 mM) in subsequent experiments. |
| Storage & Shipping | Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature. |
| Background | This gene encodes a member of the bestrophin gene family. This small gene family is characterized by proteins with a highly conserved N-terminus with four to six transmembrane domains. Bestrophins may form chloride ion channels or may regulate voltage-gated L-type calcium-ion channels. Bestrophins are generally believed to form calcium-activated chloride-ion channels in epithelial cells but they have also been shown to be highly permeable to bicarbonate ion transport in retinal tissue. Mutations in this gene are responsible for juvenile-onset vitelliform macular dystrophy (VMD2), also known as Best macular dystrophy, in addition to adult-onset vitelliform macular dystrophy (AVMD) and other retinopathies. Alternative splicing results in multiple variants encoding distinct isoforms.[provided by RefSeq, Nov 2008] |
| Usage | Research use only |
| Conjugate | Unconjugated |
Human BEST1 full length protein-synthetic nanodisc
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