| Target | |
|---|---|
| Synonyms | SISd; eoCP; SCYA5; RANTES; TCP228; D17S136E; SIS-delta |
| Description | Recombinant human CCL5 Protein with C-terminal human Fc tag |
| Delivery | In Stock |
| Uniprot ID | P13501 |
| Expression Host | HEK293 |
| Tag | C-Human Fc tag |
| Molecular Characterization | CCL5(Ser24-Ser91) hFc(Glu99-Ala330) |
| Molecular Weight | The protein has a predicted molecular mass of 34.0 kDa after removal of the signal peptide. The apparent molecular mass of CCL5-hFc is approximately 35-55 kDa due to glycosylation. |
| Purity | The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining. |
| Formulation & Reconstitution | Lyophilized from sterile PBS, pH 7.4. Normally 5 % – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions. |
| Storage & Shipping | Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing).Lyophilized proteins are shipped at ambient temperature. |
| Background | This gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, functions as a chemoattractant for blood monocytes, memory T helper cells and eosinophils. It causes the release of histamine from basophils and activates eosinophils. This cytokine is one of the major HIV-suppressive factors produced by CD8+ cells. It functions as one of the natural ligands for the chemokine receptor chemokine (C-C motif) receptor 5 (CCR5), and it suppresses in vitro replication of the R5 strains of HIV-1, which use CCR5 as a coreceptor. Alternative splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Jul 2013] |
| Usage | Research use only |
| Conjugate | Unconjugated |
Human CCL5 Protein, hFc Tag
Price: 10μg $79.00; 50μg $281.00 ; 100μg $422.00
Product Data
Images
Figure 1. Human CCL5 Protein, hFc Tag on SDS-PAGE under reducing condition.
