| Target | |
|---|---|
| Synonyms | CD38;T10;cADPr hydrolase 1 |
| Description | Recombinant human CD38 protein with C-terminal human Fc and 6×His tag |
| Delivery | In Stock |
| Uniprot ID | P28907 |
| Expression Host | HEK293 |
| Tag | C-Human Fc and 6×His Tag |
| Molecular Characterization | CD38(Val43-Ile300) hFc(Glu99-Ala330) 6×His tag |
| Molecular Weight | The protein has a predicted molecular mass of 70-72 kDa after removal of the signal peptide. |
| Purity | The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining. |
| Formulation & Reconstitution | Lyophilized from sterile PBS, pH 7.4. Normally 5 % – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution. |
| Storage & Shipping | Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature. |
| Background | CD antigen CD38 is also known as ADP-ribosyl cyclase 1, which belongs to the ADP-ribosyl cyclase family. CD38 is expressed at high levels in pancreas, liver, kidney, brain, testis, ovary, placenta, malignant lymphoma and neuroblastoma. CD38 is a multifunctional ectoenzyme that catalyzes the synthesis and hydrolysis of cyclic ADP-ribose (cADPR) from NAD to ADP-ribose. These reaction products are essential for the regulation of intracellular Ca2 . The loss of CD38 function is associated with impaired immune responses, metabolic disturbances, and behavioral modifications. The CD38 protein is a marker of cell activation. It has been connected to HIV infection, leukemias, myelomas, solid tumors, type II diabetes mellitus and bone metabolism. CD38 has been used as a prognostic marker in leukemia. |
| Usage | Research use only |
| Conjugate | Unconjugated |
Human CD38 Protein, hFc-His Tag
Price: 10μg $78.00; 50μg $310.00 ; 100 μg $460.00
Product Data
Images
Figure 1. Human CD38, hFc-His Tag on SDS-PAGE under reducing condition.
Figure 2. ELISA plate pre-coated by 2 μg/ml (100 μl/well) Human CD38, hFc-His tagged protein (PME100004) can bind Anti-CD38 Neutralizing antibody BME100004 in a linear range of 0.98-64.14 ng/ml.
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