| Target | |
|---|---|
| Synonyms | LAMP-3; ME491; MLA1; OMA81H; TSPAN30 |
| Description | Human CD63 full length protein membrane nanoparticles (MNPs) |
| Delivery | In Stock |
| Uniprot ID | P08962 |
| Expression Host | HEK293 |
| Protein Families | Druggable Genome, Transmembrane |
| Protein Pathways | Lysosome |
| Molecular Weight | The human full length CD63 protein has a MW of 25.6 kDa |
| Formulation & Reconstitution | Lyophilized from sterile PBS, pH 7.4. Normally 5 % – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution. |
| Storage & Shipping | Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature. |
| Background | The protein is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. The encoded protein is a cell surface glycoprotein that is known to complex with integrins. It may function as a blood platelet activation marker. Deficiency of this protein is associated with Hermansky-Pudlak syndrome. Also this gene has been associated with tumor progression. Alternative splicing results in multiple transcript variants encoding different protein isoforms. |
| Usage | Research use only |
| Conjugate | Unconjugated |
Human CD63 full length protein-MNP
Price: 50 μg $1200.00 ; 100 μg $1600.00
Product Data
Images
Figure1. Elisa plates were pre-coated with 0.5μg/per well purified human CD63 full length membrane nanoparticles. Serial diluted anti-CD63 monoclonal antibody (DMC100425) solutions were added, washed, and incubated with secondary antibody before Elisa reading. From above data, the EC50 for anti-CD63 monoclonal antibody binding with CD63 full length membrane nanoparticles is 61.65ng/ml.
Figure2. FACS analysis of CD63 MNPs
A. Negative Control 1: CD63 full length membrane nanoparticles samples were stained only with Goat anti-human lgG 488 secondary antibody.
B. Negative Control 2: Control membrane nanoparticles samples were stained with anti-CD63 antibody (DMC100425) at 2μg/mL, followed by Goat anti-human IgG 488 secondary antibody.
C. Negative Control 3: CD63 full length membrane nanoparticles samples were stained with anti-GPRC5D antibody (an irrelevant antibody) at 2μg/mL, followed by Goat anti-human IgG 488 secondary antibody.
D. CD63 full length membrane nanoparticles samples were stained with anti-CD63 antibody (DMC100425) at 2μg/mL, followed by Goat anti-human IgG 488 secondary antibody.
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