Name: Human CLDN4-Strep full length protein-synthetic nanodisc - DIMA Biotechnology
SKU: FLP120083

Tag	C-Flag&Strep Tag
Target	CLDN4
Synonyms	CPE-R; CPER; CPETR; CPETR1; hCPE-R; WBSCR8
Description	Human CLDN4-Strep full length protein-synthetic nanodisc
Delivery	6~8weeks
Uniprot ID	O14493
Expression Host	HEK293
Protein Families	Druggable Genome, Transmembrane
Protein Pathways	Cell adhesion molecules (CAMs), Leukocyte transendothelial migration, Tight junction
Molecular Weight	The human full length CLDN4-Strep protein has a MW of 22.1 kDa
Formulation & Reconstitution	Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions. Do not use solvents with a pH below 6.5 or those containing high concentrations of divalent metal ions (greater than 5 mM) in subsequent experiments.
Storage & Shipping	Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C(Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
Background	The protein belongs to the claudin family. Claudins are integral membrane proteins that are components of the epithelial cell tight junctions, which regulate movement of solutes and ions through the paracellular space. This protein is a high-affinity receptor for Clostridium perfringens enterotoxin (CPE) and may play a role in internal organ development and function during pre- and postnatal life. This gene is deleted in Williams-Beuren syndrome, a neurodevelopmental disorder affecting multiple systems.
Usage	Research use only
Conjugate	Unconjugated

Human CLDN4-Strep full length protein-synthetic nanodisc

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Human CLDN4-Strep full length protein-synthetic nanodisc

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