| Tag | C-Flag Tag |
|---|---|
| Target | |
| Synonyms | CD184; D2S201E; FB22; HM89; HSY3RR; LAP-3; LAP3; LCR1; LESTR; NPY3R; NPYR; NPYRL; NPYY3R; WHIM; WHIMS |
| Description | Human CXCR4 full length protein-synthetic nanodisc |
| Delivery | In Stock |
| Uniprot ID | P61073 |
| Expression Host | HEK293 |
| Protein Families | Druggable Genome, ES Cell Differentiation/IPS, GPCR, Transmembrane |
| Protein Pathways | Axon guidance, Chemokine signaling pathway, Cytokine-cytokine receptor interaction, Endocytosis, Leukocyte transendothelial migration |
| Molecular Weight | The human full length CXCR4 protein has a MW of 39.7 kDa |
| Formulation & Reconstitution | Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions. Do not use solvents with a pH below 6.5 or those containing high concentrations of divalent metal ions (greater than 5 mM) in subsequent experiments. |
| Storage & Shipping | Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature. |
| Background | A CXC chemokine receptor specific for stromal cell-derived factor-1. The protein has 7 transmembrane regions and is located on the cell surface. It acts with the CD4 protein to support HIV entry into cells and is also highly expressed in breast cancer cells. Mutations in this gene have been associated with WHIM (warts, hypogammaglobulinemia, infections, and myelokathexis) syndrome. |
| Usage | Research use only |
| Conjugate | Unconjugated |
Human CXCR4 full length protein-synthetic nanodisc
Price: 10 μg $900.00 ; 50 μg $4400.00 ; 100 μg $8000.00
Product Data
Images
Figure1. Elisa plates were pre-coated with Flag Tag CXCR4-Nanodisc (0.2μg/per well). Serial diluted anti-CXCR4 monoclonal antibody (BME100101) solutions were added, washed, and incubated with secondary antibody before Elisa reading. From above data, the EC50 for anti-CXCR4 monoclonal antibody binding with CXCR4-Nanodisc is 2442ng/ml.
Figure2. Human CXCR4-Nanodisc, Flag Tag on SDS-PAGE
Related Products
Full Length Transmembrane Proteins
SKU: FLP120074 Target: CXCR4
Price: 10 μg $810.00 ; 50 μg $3960.00 ; 100 μg $7200.00
Biosimilar reference antibodies
SKU: BME100101B Target: CXCR4
Application: Flow Cyt
Price: 50μg $99.00 ; 100 μg $199.00
Monoclonal antibodies
SKU: DMC100680B Target: CXCR4
Application: Flow Cyt
Price: 10μg $139.00 ; 100 μg $670.00 ; 500 μg $1999.00
Monoclonal antibodies
PE-conjugated Anti-CXCR4 antibody(DMC680), IgG1 Chimeric mAb
SKU: DMC100680P Target: CXCR4
Application: Flow Cyt
Price: 100 test $550.00
Biosimilar reference antibodies
SKU: BME100101P Target: CXCR4
Application: Flow Cyt
Price: 100 test $192.00