| Target | |
|---|---|
| Synonyms | FzE3 |
| Description | Recombinant Human FZD7 Protein with N-terminal human Fc tag |
| Delivery | In Stock |
| Uniprot ID | O75084 |
| Expression Host | HEK293 |
| Tag | N-Human Fc Tag |
| Molecular Characterization | hFc(Glu99-Ala330) FZD7(Gln33-Arg254) |
| Molecular Weight | The protein has a predicted molecular mass of 50.5 kDa after removal of the signal peptide. The apparent molecular mass of hFc-FZD7 is approximately 55-70 kDa due to glycosylation. |
| Purity | The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining. |
| Formulation & Reconstitution | Lyophilized from sterile PBS, pH 7.4. Normally 5 % – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution. |
| Storage & Shipping | Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature. |
| Background | Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD7 protein contains an N-terminal signal sequence, 10 cysteine residues typical of the cysteine-rich extracellular domain of Fz family members, 7 putative transmembrane domains, and an intracellular C-terminal tail with a PDZ domain-binding motif. FZD7 gene expression may downregulate APC function and enhance beta-catenin-mediated signals in poorly differentiated human esophageal carcinomas. [provided by RefSeq, Jul 2008] |
| Usage | Research use only |
| Conjugate | Unconjugated |
Human FZD7 Protein, hFc Tag
Price: 10μg $79.00; 50μg $281.00 ; 100μg $422.00
Product Data
Images
Figure 1. Human FZD7 Protein, hFc Tag on SDS-PAGE under reducing condition.
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