Human GFRAL Protein, His Tag

Price: 10μg $82.00; 50μg $320.00 ; 100 μg $480.00

SKU: PME100621 Category: ECD Proteins

Target	GFRAL
Synonyms	bA360D14.1;C6orf144;GRAL;UNQ9356
Description	Recombinant human GFRAL protein with C-terminal 6×His tag
Delivery	In Stock
Uniprot ID	Q6UXV0
Expression Host	HEK293
Tag	C-6×His Tag
Molecular Characterization	GFRAL(Ser19-Glu351) 6×His tag
Molecular Weight	The protein has a predicted molecular mass of 38.6 kDa after removal of the signal peptide. The apparent molecular mass of GFRAL-His is approximately 35-55 kDa due to glycosylation.
Purity	The purity of the protein is greater than 85% as determined by SDS-PAGE and Coomassie blue staining.
Formulation & Reconstitution	Lyophilized from sterile PBS, pH 7.4. Normally 5 % – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution.
Storage & Shipping	Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
Background	Brainstem-restricted receptor for GDF15 which regulates food intake, energy expenditure and body weight in response to metabolic and toxin-induced stresses (PubMed:28953886, PubMed:28846097, PubMed:28846098, PubMed:28846099). Upon interaction with its ligand, GDF15, interacts with RET and induces cellular signaling through activation of MAPK- and AKT- signaling pathways.[UniProtKB/Swiss-Prot Function]
Usage	Research use only
Conjugate	Unconjugated

Figure 1. Human GFRAL Protein, His Tag on SDS-PAGE under reducing condition.