| Target | |
|---|---|
| Synonyms | AITR;GITR;TNFRSF18;CD357 |
| Description | Recombinant human GITR protein with C-terminal human Fc and 6×His tag |
| Delivery | In Stock |
| Uniprot ID | Q9Y5U5 |
| Expression Host | HEK293 |
| Tag | C-Human Fc and 6×His Tag |
| Molecular Characterization | GITR(Gln26-Pro162) hFc(Glu99-Ala330) 6×His |
| Molecular Weight | The protein has a predicted molecular mass of 51-52 kDa after removal of the signal peptide. |
| Purity | The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining. |
| Formulation & Reconstitution | Lyophilized from sterile PBS, pH 7.4. Normally 5 % – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution. |
| Storage & Shipping | Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature. |
| Background | This gene encodes a member of the TNF-receptor superfamily. The encoded receptor has been shown to have increased expression upon T-cell activation, and it is thought to play a key role in dominant immunological self-tolerance maintained by CD25( )CD4( ) regulatory T cells. Knockout studies in mice also suggest the role of this receptor is in the regulation of CD3-driven T-cell activation and programmed cell death. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. |
| Usage | Research use only |
| Conjugate | Unconjugated |
Human GITR Protein, hFc-His tag
Price: 10μg $96.00; 50μg $370.00 ; 100 μg $555.00
Product Data
Images
Figure 1. Human GITR Protein, hFc-His Tag on SDS-PAGE under reducing condition.
Figure 2. Flow cytometry analysis with 1 μg/mL Human GITR Protein, hFc-His tag (PME100018) on Expi293 cells transfected with human GITRL (Blue histogram) or Expi293 transfected with irrelevant protein (Red histogram).
Related Products
Monoclonal antibodies
SKU: DME100078P Target: GITR
Application: Flow Cyt
Price: 100 test $550.00
Biosimilar reference antibodies
SKU: BME100065 Target: GITR
Application: Flow Cyt
Price: 50μg $82.00 ; 100 μg $162.00
Biosimilar reference antibodies
SKU: BME100065P Target: GITR
Application: Flow Cyt
Price: 100 test $192.00
Monoclonal antibodies
SKU: DME100080P Target: GITR
Application: Flow Cyt
Price: 100 test $550.00
DiSliceX
SKU: SLI100001 Target: BCMA, BTN3A1, CD138, CD147, CD30, CD33, CD38, CD47, CD63, CD99, CS1, GITR, GPC1, GPRC5D, ICAM-1, MUC1, PDL-1, SELPLG, TFRC, TIM3
Application: IHC
Price: 2 slides $129.00