| Tag | C-Flag Tag |
|---|---|
| Target | |
| Synonyms | BG37, GPCR19, GPR131, M-BAR, TGR5 |
| Description | Human GPBAR full length protein-synthetic nanodisc |
| Delivery | 6~8weeks |
| Uniprot ID | Q8TDU6 |
| Expression Host | HEK293 |
| Protein Families | Druggable Genome, |
| Protein Pathways | N/A |
| Molecular Weight | The human full length GPBAR protein has a MW of 35.2kDa |
| Formulation & Reconstitution | Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions. Do not use solvents with a pH below 6.5 or those containing high concentrations of divalent metal ions (greater than 5 mM) in subsequent experiments. |
| Storage & Shipping | Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature. |
| Background | This gene encodes a member of the G protein-coupled receptor (GPCR) superfamily. This enzyme functions as a cell surface receptor for bile acids. Treatment of cells expressing this GPCR with bile acids induces the production of intracellular cAMP, activation of a MAP kinase signaling pathway, and internalization of the receptor. The receptor is implicated in the suppression of macrophage functions and regulation of energy homeostasis by bile acids. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008] |
| Usage | Research use only |
| Conjugate | Unconjugated |
Human GPBAR full length protein-synthetic nanodisc
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