| Target | |
|---|---|
| Synonyms | Interleukin-2;IL-2;T-Cell Growth Factor;TCGF;Aldesleukin;IL2 |
| Description | Recombinant Human Interleukin-2 Superkine is produced by our Mammalian expression system and the target gene encoding Ala21-Thr153 (L100F, R101D, L105V, I106V, I112F) is expressed with a 6His tag at the C-terminus. |
| Delivery | In Stock |
| Uniprot ID | P60568 |
| Expression Host | HEK293 |
| Tag | C-6×His Tag |
| Molecular Characterization | Not available |
| Molecular Weight | 16.5 KDa |
| Purity | Greater than 95% as determined by reducing SDS-PAGE. |
| Formulation & Reconstitution | Lyophilized from a 0.2 μm filtered solution of 4mM HCl. |
| Storage & Shipping | Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature. |
| Background | Interleukin-2(IL-2) is an interleukin, a type of cytokine signaling molecule in the immune system,belongs to the IL-2 family. It is a powerful immunoregulatory lymphokine produced by T-cells in response to antigenic or mitogenic stimulation. IL-2/IL-2R signaling is required for T-cell proliferation and other fundamental functions that are essential for the immune response. IL-2 stimulates growth and differentiation of B-cells, NK cells, lymphokine-activated killer cells, monocytes, macrophages and oligodendrocytes. New research has shown that IL-2 mutant reduced toxicity while being more potent at stimulating anti-tumor effector immune cells. |
| Usage | Research use only |
| Conjugate | Unconjugated |
Human IL-2 Superkine (Mutant, C-6His) Protein
Price: 50 μg $171.00
Product Data
Images
Figure 1. Greater than 95% as determined by reducing SDS-PAGE.
Figure 2. Loaded Human IL-2RB-Fc on Protein A Biosensor, can bind Human IL-2 Superkine with an affinity constant of 0.58 nM as determined in BLI assay.
Figure 3. Measured in a cell proliferation assay using CTLL‑2 mouse cytotoxic T cells. The ED50 for this effect is 151.39 pg/ml.
Figure 4. Loaded Human IL-2RA-Fc on Protein A Biosensor, can bind Human IL-2 Superkine with an affinity constant of 10.4 nM as determined in BLI assay.
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