| Target | |
|---|---|
| Synonyms | IL21;Za11;Interleukin-21 |
| Description | Recombinant Human IL21 with C-terminal Human Fc tag |
| Delivery | In Stock |
| Uniprot ID | Q9HBE4 |
| Expression Host | HEK293 |
| Tag | C-Human Fc Tag |
| Molecular Characterization | IL21(Gln30-Ser162) hFc(Glu99-Ala330) |
| Molecular Weight | The protein has a predicted molecular mass of 41.6 kDa after removal of the signal peptide.The apparent molecular mass of IL21-hFc is approximately 35-55 kDa due to glycosylation. |
| Purity | The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining. |
| Formulation & Reconstitution | Lyophilized from sterile PBS, pH 7.4. Normally 5 % – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution. |
| Storage & Shipping | Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature. |
| Background | This gene encodes a member of the common-gamma chain family of cytokines with immunoregulatory activity. The encoded protein plays a role in both the innate and adaptive immune responses by inducing the differentiation, proliferation and activity of multiple target cells including macrophages, natural killer cells, B cells and cytotoxic T cells. Dysregulation of this gene plays a role in multiple immune-mediated diseases including lupus, psoriasis and chronic inflammatory diseases. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011] |
| Usage | Research use only |
| Conjugate | Unconjugated |
Human IL21 Protein, hFc Tag
Price: 10μg $78.00; 50μg $310.00 ; 100 μg $460.00
Product Data
Images
Figure 1. Human IL21 Protein, hFc Tag on SDS-PAGE under reducing condition.
Figure 2. ELISA plate pre-coated by 2 μg/ml (100 μl/well) Human IL21R, His tagged protein PME100587 can bind Human IL21, hFc Tagged protein (PME101088) in a linear range of 1.6-40 ng/ml.
Figure 3. ELISA plate pre-coated by 2 μg/mL (100 μL/well) Human IL21 Protein, hFc Tag ( PME101088) can bind Anti-IL21 Neutralizing antibody BME100103 in a linear range of 2.44–156.25 ng/mL.
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