| Tag | N-MBP Tag, C-Flag Tag |
|---|---|
| Target | |
| Synonyms | Claudin 6, Claudin-6, Skullin,Claudin6 |
| Description | Human MBP-CLDN6 full length protein-synthetic nanodisc |
| Delivery | In Stock |
| Uniprot ID | P56747 |
| Expression Host | HEK293 |
| Protein Families | Transmembrane |
| Protein Pathways | Cell adhesion molecules (CAMs), Leukocyte transendothelial migration, Tight junction |
| Molecular Weight | The human full length MBP-CLDN6 Protein has a MW of 63.3 kDa |
| Formulation & Reconstitution | Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for |
| Storage & Shipping | Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature. |
| Background | Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. This gene encodes a component of tight junction strands, which is a member of the claudin family. The protein is an integral membrane protein and is one of the entry cofactors for hepatitis C virus. The gene methylation may be involved in esophageal tumorigenesis. This gene is adjacent to another family member CLDN9 on chromosome 16. |
| Usage | Research use only |
| Conjugate | Unconjugated |
Human MBP-CLDN6 full length protein-synthetic nanodisc
Price: 10 μg $900.00 ; 50 μg $4400.00 ; 100 μg $8000.00
Product Data
Images
Figure 1. Elisa plates were pre-coated with N-MBP Tag, C-Flag Tag MBP-CLDN6-Nanodisc (0.2μg/per well). Serial diluted anti-CLDN6 monoclonal antibody (BME100082) solutions were added, washed, and incubated with secondary antibody before Elisa reading. From above data, the EC50 for anti-CLDN6 monoclonal antibody binding with MBP-CLDN6-Nanodisc is 723.6ng/ml.
Figure 2. Human MBP-CLDN6-Nanodisc with N-MBP Tag, C-Flag Tag on SDS-PAGE
Related Products
Biosimilar reference antibodies
SKU: BME100082P Target: CLDN6
Application: Flow Cyt
Price: 100 test $192.00
Monoclonal antibodies
SKU: DMC101199B Target: CLDN6
Application: Flow Cyt
Price: 10μg $139.00 ; 100 μg $670.00 ; 500 μg $1999.00
ECD Proteins
SKU: PME101207 Target: CLDN6
Price: 10μg $70.00; 50μg $244.00 ; 100μg $367.00
Monoclonal antibodies
SKU: DMC101200B Target: CLDN6
Application: Flow Cyt
Price: 10μg $139.00 ; 100 μg $670.00 ; 500 μg $1999.00
Monoclonal antibodies
SKU: DMC101201B Target: CLDN6
Application: Flow Cyt
Price: 10μg $139.00 ; 100 μg $670.00 ; 500 μg $1999.00