Human pro-BDNF Protein

Price: 50 μg $360.00

SKU: PME30058 Category: ECD Proteins

Target	pro-BDNF
Synonyms	Brain-Derived Neurotrophic Factor;BDNF;Abrineurin
Description	Recombinant Human Pro-Brain-Derived Neurotrophic Factor is produced by our E.coli expression system and the target gene encoding Ala19-Arg247(R125A,R127A,R128A) is expressed.
Delivery	In Stock
Uniprot ID	P23560
Expression Host	E.coli
Tag
Molecular Characterization	Not available
Molecular Weight	25.6 KDa
Purity	Greater than 95% as determined by reducing SDS-PAGE.
Formulation & Reconstitution	Lyophilized from a 0.2 μm filtered solution of PBS, pH 8.0.
Storage & Shipping	Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
Background	The precursor form of Brain-Derived Neurotrophic Factor (pro-BDNF) interacts preferentially with the pan-neurotrophin receptor p75 (p75NTR) and vps10p domain-containing receptor sortilin and induces neuronal apoptosis, whereas mature BDNF selectively binds with high affinity to the TrkB kinase receptor and promotes the survival, growth and differentiation of neurons. As proneurotrophins and mature neurotrophins elicit opposite biological effects, Pro-BDNF cleavage in the neuronal system is regulated in a specific and cell-context dependent manner. Pro-BDNF plays important role in negative regulation of neurotrophic actions in the brain.
Usage	Research use only
Conjugate	Unconjugated

Figure 1. Greater than 95% as determined by reducing SDS-PAGE.