| Tag | C-Flag Tag |
|---|---|
| Target | |
| Synonyms | EKNS, PFE, PTHR, PTHR1 |
| Description | Human PTH1R full length protein-synthetic nanodisc |
| Delivery | 6~8weeks |
| Uniprot ID | Q03431 |
| Expression Host | HEK293 |
| Protein Families | GPCR,Transmembrane,Druggable Genome, |
| Protein Pathways | Endochondral Ossification,GPCRDB Class B Secretin-like,Osteoblasts,Cancer, |
| Molecular Weight | The human full length PTH1R protein has a MW of 66.4kDa |
| Formulation & Reconstitution | Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions. Do not use solvents with a pH below 6.5 or those containing high concentrations of divalent metal ions (greater than 5 mM) in subsequent experiments. |
| Storage & Shipping | Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature. |
| Background | The protein encoded by this gene is a member of the G-protein coupled receptor family 2. This protein is a receptor for parathyroid hormone (PTH) and for parathyroid hormone-like hormone (PTHLH). The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system. Defects in this receptor are known to be the cause of Jansen's metaphyseal chondrodysplasia (JMC), chondrodysplasia Blomstrand type (BOCD), as well as enchodromatosis. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, May 2010] |
| Usage | Research use only |
| Conjugate | Unconjugated |
Human PTH1R full length protein-synthetic nanodisc
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