| Target | |
|---|---|
| Synonyms | HAVCR2; CD366; KIM-3; SPTCL; TIMD3; Tim-3; TIMD-3; HAVcr-2 |
| Description | Recombinant human TIM3 Protein with C-terminal human Fc tag |
| Delivery | In Stock |
| Uniprot ID | Q8TDQ0 |
| Expression Host | HEK293 |
| Tag | C-Human Fc tag |
| Molecular Characterization | TIM3(Ser22-Gly202) hFc(Glu99-Ala330) |
| Molecular Weight | The protein has a predicted molecular mass of 46.1 kDa after removal of the signal peptide. The apparent molecular mass of TIM3-hFc is approximately 55-100 kDa due to glycosylation. |
| Purity | The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining. |
| Formulation & Reconstitution | Lyophilized from sterile PBS, pH 7.4. Normally 5 % – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution. |
| Storage & Shipping | Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature. |
| Background | The protein encoded by this gene belongs to the immunoglobulin superfamily, and TIM family of proteins. CD4-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas, Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. This protein is a Th1-specific cell surface protein that regulates macrophage activation, and inhibits Th1-mediated auto- and alloimmune responses, and promotes immunological tolerance. [provided by RefSeq, Sep 2011] |
| Usage | Research use only |
| Conjugate | Unconjugated |
Human TIM3 Protein, hFc Tag
Price: 10μg $118.00; 50μg $429.00 ; 100 μg $645.00
Product Data
Images
Figure 1. Human TIM3 Protein, hFc Tag on SDS-PAGE under reducing condition.
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