| Target | |
|---|---|
| Synonyms | BTLA;D272 |
| Description | Recombinant mouse BTLA protein with C-terminal mFc tag |
| Delivery | In Stock |
| Uniprot ID | Q7TSA3 |
| Expression Host | HEK293 |
| Tag | C-Mouse Fc Tag |
| Molecular Characterization | Mouse BTLA(Glu30-Pro176) mFc(Pro99-Lys330) |
| Molecular Weight | The protein has a predicted molecular mass of 42.7 kDa after removal of the signal peptide.The apparent molecular mass of Mouse-BTLA-mFc is approximately 55-70 kDa due to glycosylation. |
| Purity | The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining. |
| Formulation & Reconstitution | Lyophilized from sterile PBS, pH 7.4. Normally 5 % – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution. |
| Storage & Shipping | Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature. |
| Background | Inhibitory receptor on lymphocytes that negatively regulates antigen receptor signaling via PTPN6/SHP-1 and PTPN11/SHP-2 (PubMed:12796776, PubMed:14652006). May interact in cis (on the same cell) or in trans (on other cells) with TNFRSF14 (PubMed:19915044). In cis interactions, appears to play an immune regulatory role inhibiting in trans interactions in naive T cells to maintain a resting state. In trans interactions, can predominate during adaptive immune response to provide survival signals to effector T cells (PubMed:19915044). |
| Usage | Research use only |
| Conjugate | Unconjugated |
Mouse BTLA Protein, mFc Tag
Price: 10μg $78.00; 50μg $310.00 ; 100 μg $460.00
Product Data
Images
Figure 1. Mouse BTLA Protein, mFc Tag on SDS-PAGE under reducing condition.
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