Target | |
---|---|
Synonyms | TREM-2;Trem2a;Trem2b;Trem2c |
Description | Recombinant mouse TREM2 protein with C-terminal human Fc tag |
Delivery | In Stock |
Uniprot ID | Q99NH8 |
Expression Host | HEK293 |
Tag | C-Human Fc Tag |
Molecular Characterization | Mouse TREM2(Leu19-Ser171) hFc(Glu99-Ala330) |
Molecular Weight | The protein has a predicted molecular mass of 42.9 kDa after removal of the signal peptide. |
Purity | The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining. |
Formulation & Reconstitution | Lyophilized from sterile PBS, pH 7.4. Normally 5 % – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution. |
Storage & Shipping | Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature. |
Background | The protein encoded by this gene is part of the immunoglobulin and lectin-like superfamily and functions as part of the innate immune system. This gene forms part of a cluster of genes on mouse chromosome 17 thought to be involved in innate immunity. This protein associates with the adaptor protein Dap-12 and recruits several factors, such as kinases and phospholipase C-gamma, to form a receptor signaling complex that activates myeloid cells, including dendritic cells and microglia. In humans homozygous loss-of-function mutations in this gene cause Nasu-Hakola disease and mutations in this gene may be risk factors to the development of Alzheimer's disease. In mouse mutations of this gene serve as a pathophysiological model for polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (Nasu-Hakola disease) and for inflammatory bowel disease. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jan 2013] |
Usage | Research use only |
Conjugate | Unconjugated |
Mouse TREM2 Protein, hFc Tag
Price: 10μg $75.00; 50μg $259.00 ; 100μg $389.00
Product Data
Images
PME-M100080
Figure 1. Mouse TREM2 Protein, hFc Tag on SDS-PAGE under reducing condition.
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