Clone ID | DM143 |
---|---|
Target | |
Synonyms | BAFFR;TNFRSF13C;BAFF-R;BROMIX;CD268;CVID4;prolixin |
Host Species | Rabbit |
Description | PE-conjugated Anti-BAFF-R antibody(DM143); Rabbit mAb |
Delivery | 3-4 weeks |
Uniprot ID | Q96RJ3 |
IgG type | Rabbit IgG |
Clonality | Monoclonal |
Reactivity | Human |
Applications | Flow Cyt |
Recommended Dilutions | Flow Cyt 1:100 |
Purification | Purified from cell culture supernatant by affinity chromatography |
Formulation & Reconstitution | Liquid,PBS with 0.05% Proclin300, 1% BSA |
Storage & Shipping | Store at 2°C-8°C for 6 months |
Background | B cell-activating factor (BAFF) enhances B-cell survival in vitro and is a regulator of the peripheral B-cell population. Overexpression of Baff in mice results in mature B-cell hyperplasia and symptoms of systemic lupus erythematosus (SLE). Also; some SLE patients have increased levels of BAFF in serum. Therefore; it has been proposed that abnormally high levels of BAFF may contribute to the pathogenesis of autoimmune diseases by enhancing the survival of autoreactive B cells. The protein encoded by this gene is a receptor for BAFF and is a type III transmembrane protein containing a single extracellular cysteine-rich domain. It is thought that this receptor is the principal receptor required for BAFF-mediated mature B-cell survival. |
Usage | Research use only |
Conjugate | PE-conjugated |
PE-conjugated Anti-BAFF-R antibody(DM143); Rabbit mAb
Price: 100 test $550.00
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