Clone ID | DMC446 |
---|---|
Target | |
Synonyms | C-Kit; CD117; MASTC; PBT; SCFR; KIT |
Host Species | Rabbit |
Description | PE-conjugated Anti-CD117 antibody(DMC446), IgG1 Chimeric mAb |
Delivery | 3-4 weeks |
Uniprot ID | P10721 |
IgG type | Rabbit/Human Fc chimeric IgG1 |
Clonality | Monoclonal |
Reactivity | Human |
Applications | Flow Cyt |
Recommended Dilutions | Flow Cyt 1:100 |
Purification | Purified from cell culture supernatant by affinity chromatography |
Formulation & Reconstitution | Liquid,PBS with 0.05% Proclin300, 1% BSA |
Storage & Shipping | Store at 2°C-8°C for 6 months |
Background | This gene encodes a receptor tyrosine kinase. This gene was initially identified as a homolog of the feline sarcoma viral oncogene v-kit and is often referred to as proto-oncogene c-Kit. The canonical form of this glycosylated transmembrane protein has an N-terminal extracellular region with five immunoglobulin-like domains; a transmembrane region; and an intracellular tyrosine kinase domain at the C-terminus. Upon activation by its cytokine ligand; stem cell factor (SCF); this protein phosphorylates multiple intracellular proteins that play a role in in the proliferation; differentiation; migration and apoptosis of many cell types and thereby plays an important role in hematopoiesis; stem cell maintenance; gametogenesis; melanogenesis; and in mast cell development; migration and function. This protein can be a membrane-bound or soluble protein. Mutations in this gene are associated with gastrointestinal stromal tumors; mast cell disease; acute myelogenous leukemia; and piebaldism. Multiple transcript variants encoding different isoforms have been found for this gene. |
Usage | Research use only |
Conjugate | PE-conjugated |
PE-conjugated Anti-CD117 antibody(DMC446), IgG1 Chimeric mAb
Price: 100 test $550.00
Product Data
Images
Related Products
ECD Proteins
SKU: PME101602 Target: CD117
Price: 10μg $85.00; 50μg $330.00 ; 100 μg $500.00
ECD Proteins
SKU: PME101621 Target: CD117
Price: 10μg $85.00; 50μg $330.00 ; 100 μg $500.00
Monoclonal antibodies
SKU: DMC100446B Target: CD117
Application: Flow Cyt
Price: 10μg $139.00 ; 100 μg $670.00 ; 500 μg $1999.00
Biosimilar reference antibodies
SKU: BME100423 Target: CD117
Application: N/A
Price: 50μg $82.00 ; 100 μg $162.00
ECD Proteins
SKU: PME101603 Target: CD117
Price: 10μg $85.00; 50μg $330.00 ; 100 μg $500.00