Clone ID | DMC369 |
---|---|
Target | |
Synonyms | ERBB2;CD340;HER-2:neu;HER2;MLN19;NEU;NGL;TKR1 |
Host Species | Rabbit |
Description | PE-conjugated Anti-HER2 antibody(DMC369); IgG1 Chimeric mAb |
Delivery | 3-4 weeks |
Uniprot ID | P04626 |
IgG type | Rabbit/Human Fc chimeric IgG1 |
Clonality | Monoclonal |
Reactivity | Human |
Applications | Flow Cyt |
Recommended Dilutions | Flow Cyt 1:100 |
Purification | Purified from cell culture supernatant by affinity chromatography |
Formulation & Reconstitution | Liquid,PBS with 0.05% Proclin300, 1% BSA |
Storage & Shipping | Store at 2°C-8°C for 6 months |
Background | This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However; it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer; stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways; such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported; with the most common allele; Ile654:Ile655; shown here. Amplification and:or overexpression of this gene has been reported in numerous cancers; including breast and ovarian tumors. Alternative splicing results in several additional transcript variants; some encoding different isoforms and others that have not been fully characterized. |
Usage | Research use only |
Conjugate | PE-conjugated |
PE-conjugated Anti-HER2 antibody(DMC369); IgG1 Chimeric mAb
Price: 100 test $550.00
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