Name: Human KCD17-Strep full length protein-synthetic nanodisc - DIMA Biotechnology
SKU: FLP120698

Tag	C-Flag&Strep Tag
Target	KCD17
Synonyms	N/A
Description	Human KCD17-Strep full length protein-synthetic nanodisc
Delivery	6~8weeks
Uniprot ID	Q8N5Z5
Expression Host	HEK293
Protein Families	Ion Channels: Other
Protein Pathways	N/A
Molecular Weight	The human full length KCD17-Strep protein has a MW of 35.7 kDa
Formulation & Reconstitution	Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions. Do not use solvents with a pH below 6.5 or those containing high concentrations of divalent metal ions (greater than 5 mM) in subsequent experiments.
Storage & Shipping	Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
Background	This gene encodes a protein that belongs to a conserved family of potassium channel tetramerization domain (KCTD)-containing proteins. The encoded protein functions in ciliogenesis by acting as a substrate adaptor for the cullin3-based ubiquitin-conjugating enzyme E3 ligase, and targets trichoplein, a keratin-binding protein, for degradation via polyubiquitinylation. A mutation in this gene is associated with autosomal dominant myoclonic dystonia 26. [provided by RefSeq, Nov 2016]
Usage	Research use only
Conjugate	Unconjugated

Human KCD17-Strep full length protein-synthetic nanodisc