| Tag | C-Flag&Strep Tag |
|---|---|
| Target | |
| Synonyms | EDG8, Edg-8, S1P5, SPPR-1, SPPR-2 |
| Description | Human S1PR5-Strep full length protein-synthetic nanodisc |
| Delivery | 6~8weeks |
| Uniprot ID | Q9H228 |
| Expression Host | HEK293 |
| Protein Families | GPCR,Transmembrane,Druggable Genome, |
| Protein Pathways | S1P Signaling, |
| Molecular Weight | The human full length S1PR5-Strep protein has a MW of 41.8 kDa |
| Formulation & Reconstitution | Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% – 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions. Do not use solvents with a pH below 6.5 or those containing high concentrations of divalent metal ions (greater than 5 mM) in subsequent experiments. |
| Storage & Shipping | Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature. |
| Background | The lysosphingolipid sphingosine 1-phosphate (S1P) regulates cell proliferation, apoptosis, motility, and neurite retraction. Its actions may be both intracellular as a second messenger and extracellular as a receptor ligand. S1P and the structurally related lysolipid mediator lysophosphatidic acid (LPA) signal cells through a set of G protein-coupled receptors known as EDG receptors. Some EDG receptors (e.g., EDG1; MIM 601974) are S1P receptors; others (e.g., EDG2; MIM 602282) are LPA receptors.[supplied by OMIM, Mar 2008] |
| Usage | Research use only |
| Conjugate | Unconjugated |
Human S1PR5-Strep full length protein-synthetic nanodisc
Price: 10 μg $810.00 ; 50 μg $3960.00 ; 100 μg $7200.00
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